Mariel (María Villar) longs to play the role of Isabella in a local theater troupe's production of Shakespeare's Measure for Measure, but money problems prevent her from preparing for the audition. She thinks of asking her brother for financial help, but is worried about being too direct. Her solution is to ask her brother's girlfriend, Luciana (Agustina Muñoz), also an actress and a more self-assured one, to convince her brother to give her the money. Luciana agrees on the condition that Mariel will not abandon her acting and continue to prepare for the part of Isabella.

The latest in Matías Piñeiro's series of films inspired by the women of Shakespeare's comedies is his most structurally daring and visually stunning work to date. Through their rich and layered performances, Muñoz and Villar demonstrate a profound intimacy formed over more than a decade of collaboration with their director. Isabella is a film about the ongoing battle between doubt and ambition that never discounts the possibility of a new beginning.